منابع مشابه
Shaping the intestinal brush border
Epithelial cells from diverse tissues, including the enterocytes that line the intestinal tract, remodel their apical surface during differentiation to form a brush border: an array of actin-supported membrane protrusions known as microvilli that increases the functional capacity of the tissue. Although our understanding of how epithelial cells assemble, stabilize, and organize apical microvill...
متن کاملRat Intestinal Brush Border Membrane Peptidases
The properties of two purified peptidases derived from the intestinal brush border membrane of the rat have been investigated. The pH optima, heat stabilities, substrate specificities, and metal ion requirements of the two enzymes and the effects of inhibitors on their activities were nearly identical. The isoenzymes catalyzed the hydrolysis of a wide range of peptides containing from 2 to 8 am...
متن کاملMultiple unconventional myosin domains of the intestinal brush border cytoskeleton.
Representatives of class V and class VI unconventional myosins are identified as components of the intestinal brush border cytoskeleton. With brush border myosin-I and myosin-II, this brings to four the number of myosin classes associated with this one subcellular domain and represents the first characterization of four classes of myosins expressed in a single metazoan cell type. The distributi...
متن کاملATP-driven copper transport across the intestinal brush border membrane.
The divalent metal ion transporter DMT1 is localized in the brush border membrane (BBM) of the upper small intestine and has been shown to be able to transport Mn2+, Fe2+, Co2+, Ni2+, and Cu2+. Belgrade rats have a glycine-to-arginine (G185R) mutation in DMT1, which affects its function. We investigated copper transport with BBM vesicles of Belgrade rats loaded with calcein, which exhibits fluo...
متن کاملLocalized Lanthanum Staining of the Intestinal Brush Border
The use of lanthanum salts has made possible the staining of extracellular regions which are not electron opaque when conventional methods of fixation and staining for electron microscopy are employed (3, 6, 10). The present work describes the staining of the intestinal epithelium by this means. Intercellular regions in the intestinal wall generally stain intensely, as has been described previo...
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ژورنال
عنوان ژورنال: Gut
سال: 1971
ISSN: 0017-5749
DOI: 10.1136/gut.12.8.668